ST. CLOUD, Minn. (CNS) — Who could have predicted that a student from St. Mary’s Grade School in Little Falls would one day win a Nobel Prize? But that’s what Dr. Brian Kobilka accomplished.
He’s one of two scientists awarded a Nobel Prize in Chemistry Oct. 10 for their work on cell receptors.
“It’s a great honor for me,” Kobilka told The Visitor, newspaper of the Diocese of St. Cloud. He made the comments in a telephone interview from his lab in the department of molecular and cellular physiology and medicine at Stanford University in Stanford, Calif.
Kobilka, 57, physician and professor at Stanford University School of Medicine, shares the prize with his onetime mentor Robert Lefkowitz, professor at Duke University Medical Center in Durham, N.C. Since 1984, the pair has worked to identify and isolate a particular family of cell receptors, called G-protein-coupled receptors, or GPCRs, which carry signals from outside stimuli to cells of the human body.
The Royal Swedish Academy of Sciences website includes an essay on the winners’ work, “Cells and sensibility,” as general background for the science.
In their introduction: “In our eyes, noses and mouths, we have sensors for light, odors and flavors. Within the body, cells have similar sensors for hormones and signaling substances, such as adrenalin, serotonin, histamine and dopamine. As life evolved, cells have repeatedly used the same basic mechanism for reading their environment: G-protein-coupled receptors. But they remained hidden from researchers for a long time.”
Their essay further described the two scientists’ persistence in trying to capture an image of the receptor, a goal believed unattainable by most of the scientific community, and their groundbreaking discoveries in mapping how the GPCR family of receptors works.
Though often Nobel Prizes are given for work done much earlier, Kobilka said in his case the work that had the greatest impact was published only last year in Nature, an international journal for science and medicine.
In 2011, Kobilka’s lab captured through X-ray crystallography the first image of a living G-protein receptor on a cell membrane precisely when it transferred the signal from the hormone adrenalin on the outside of the cell to its interior. The image revealed new details about the GPCRs.
Because of the insights of Lefkowitz and Kobilka, pharmaceutical companies are able to develop more effective and safer medicines for a wide range of diseases.
“About half the drugs a physician would administer,” Kobilka said, “particularly to patients in an intensive care setting, work on cell receptors.”
Those drugs include beta blockers for heart disease, antihistamines for inflammatory disease, various psychiatric medications, drugs for ulcers and those which help the immune system combat cancers.
“We’re still doing similar research,” he said, “focusing on trying to develop methods of making what we’ve learned more applicable for more effective drugs.”
Kobilka talked about growing up in Minnesota, recalling: “The entire time I lived in Little Falls I attended Mass at St. Mary’s. Msgr. (T. Leo) Keaveny was our priest.”
Currently, Kobilka and his wife, Tong Sun Kobilka, are members of the Catholic Community at Stanford, which is in the Diocese of San Jose, Calif.
“My introduction to science came through a friend several years older who was interested in all things science you can do at a young age,” he told The Visitor. “He did experiments in electronics and had a chemistry set, which he shared with me. I caught my interest from him.”
Kobilka further credits excellent math and science teachers at Little Falls High School, where he graduated in 1973, and at University of Minnesota-Duluth, who helped him pursue his zeal.
He likewise encouraged young scientists, possible future Nobel laureates, to follow their passions.
“Work on what you’re interested in,” he said, “on what you want to understand, like how some aspect of how life works. It could be humans or how the universe was created, physics, planetary science, light, the complex relationships between matter and space, medicine, chemistry. If you try to do something because someone wants you to, you’re less likely to succeed.
“What drives people to succeed is doing something that follows their natural instincts and curiosity.”
Rajala is on the staff of The Visitor, newspaper of the Diocese of St. Cloud.
Join the CatholicPhilly.com family
CatholicPhilly.com works to strengthen the connections between people, families and communities every day by delivering the news people need to know about the Catholic Church, especially in the Philadelphia region, and the world in which we live.
By your donation in any amount, you and hundreds of other people become part of our mission to inform, form in the Catholic faith and inspire the thousands of readers who visit every month.
Here is how you can help:
- A $100 gift allows us to present award-winning photos of Catholic life in our neighborhoods.
- A $50 gift enables us to cover a news event in a local parish, school or Catholic institution.
- A $20 gift lets us obtain solid faith formation resources that can deepen your spirituality and knowledge of the faith.
- A small, automated monthly donation means you can support us continually and easily.
Won't you consider making a gift today?
Please join in the church's vital mission of communications by offering a gift in whatever amount that you can ― a single gift of $40, $50, $100, or more, or a monthly donation. Your gift will strengthen the fabric of our entire Catholic community and sustain CatholicPhilly.com as your trusted news source. Thank you in advance!
Make your donation by credit card here:
Or make your donation by check:
222 N. 17th Street
Philadelphia, PA 19103
PREVIOUS: Spokane Diocese accuses law firm that handled bankruptcy of malpractice
NEXT: Essayists say church teachings have given them ‘true freedom’ as women
Share this story